Colofac mebeverine Colofac is an antispasmodic of myotropic action. Its main constituent is Mebeverine. Has a direct effect on the smooth muscles of the gastrointestinal tract. The preparation eliminates spasm without affecting normal intestinal motility. It does not possess anticholinergic action. This formulation allows dosing schedule 2 times a day.


Colofac mebeverine Colofac completely metabolizes in the human body. The first step of the metabolism is hydrolysis to form veratric acid and Mebeverine.

Mebeverine violates the entrance of Na + ions into the cell by preventing the fast sodium channels myocyte cell membrane, also it blocks the entering through the slow channels of ions Ca2 +, hinders the process of depolarization of the cell membrane and prevents the reduction of muscle fibers. Mebeverine does not have an anticholinergic action. It directly relaxes smooth muscle, mainly in the gastrointestinal tract. The preparation eliminates spasm, without exerting a significant effect on the normal intestinal peristalsis.

The preparation is mainly removed in urine as metabolites only. Mebeverine is removed completely within days after a single dose. The body does not cumulate this constituent.

Indications for the Usage

  • symptomatic curing of pain, cramps, dysfunction and discomfort in the intestine associated with irritable bowel syndrome.
  • curing of spasms of the digestive tract.

Dosing and Administration

Mebeverine structure 3d

Colofac is taken orally 20 minutes before a meal without chewing and drinking water. Examinees older than 12 years should the preparation 2 times daily (200 mg.). The capsule must be swallowed without chewing, and drank with water. The duration of curing is determined by the physician individually.

Because of the possibility of the development of dizziness while the curing with Mebeverine, examinees must be especially careful in the operating of mechanisms and machines, driving vehicles.


There has been observed only one severe contraindication to Colofac – the hypersensitivity to the constituents.

Mebeverine in capsules is not intended for usage in children.

Since the preparation does not show the usual anticholinergic adverse effects, it can be used by examinees with prostatic hypertrophy and glaucoma.

In appointing of the preparation during pregnancy must be weighed the profit to the mother and the possible danger to the fetus. When administered in therapeutic doses Mebeverine does not penetrate into breast milk, therefore its usage during lactation is allowed.


  • Adults: spasms of the gastrointestinal tract (including those which are due to organic disease), biliary colic, intestinal colic; Irritable bowel syndrome (curing of pain and spasms and disorders and intestinal discomfort).
  • Children over 12 years: functional disorders of the gastrointestinal tract, accompanied by abdominal pain.

Adverse Effects

The preparation may cause such adverse effects:

  • Constipation.
  • Diarrhea.
  • Dizziness (in some cases).
  • Allergic reactions (angioedema, urticaria, rash and swelling of the face).


If you overuse Colofac there develops the excitation of central nervous system. It is quite important to contact a specialist in the shortest terms to avoid unwanted effects. The usual treatment, when the overdose occurs, is gastric lavage and symptomatic therapy. The specific antidote is not known.

Remember! Self-treatment can be perilous for your health. Do not undergo any course of curing without proper consulting at a specialist.